This striking heterogeneity of cyclooxygenase expression between the different kidney zones was paralleled by the tissue concentrations of PGE 2, which were 50 fold higher in the inner medulla when compared with the cortex, confirming the inner medulla as the main site of PGE 2 formation in the kidney 27, 28 nolvadex Pharmacological group, as a result, kY Leading Board Certified Urologist who has practiced for more than 25 years